Deutsche medizinische Wochenschrift (1946) · 2003
[Pantoprazole-induced hepatitis].
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Cordes A, Vogt W, Maier K P
Аннотация
HISTORY: A 46-year-old woman presented for an emergency admission because of colic-like upper abdominal pain and markedly impaired general condition. Eight days before admission she had started and continued to take pantoprazole because of symptoms of gastroesophageal reflux.
INVESTIGATIONS: Clinical examination and laboratory tests indicated abnormal liver functions suggesting hepatitis. Serology largely excluded an infectious, autoimmunological or metabolic cause. Duplex sonography gave no evidence of bile obstruction or Budd-Chiari syndrome.
DIAGNOSIS AND COURSE: The patient's condition and laboratory tests after the drug had been discontinued gradually improved on symptomatic treatment, indicating pantoprazole-induced hepatitis.
CONCLUSION: Intake of proton pump inhibitors is a rare cause but should be considered in the differential diagnosis of hepatitis of uncertain etiology.
INVESTIGATIONS: Clinical examination and laboratory tests indicated abnormal liver functions suggesting hepatitis. Serology largely excluded an infectious, autoimmunological or metabolic cause. Duplex sonography gave no evidence of bile obstruction or Budd-Chiari syndrome.
DIAGNOSIS AND COURSE: The patient's condition and laboratory tests after the drug had been discontinued gradually improved on symptomatic treatment, indicating pantoprazole-induced hepatitis.
CONCLUSION: Intake of proton pump inhibitors is a rare cause but should be considered in the differential diagnosis of hepatitis of uncertain etiology.
Предметные рубрики MeSH
2-PyridinylmethylsulfinylbenzimidazolesAbdomenAbdominal PainAnti-Ulcer AgentsBenzimidazolesChemical and Drug Induced Liver InjuryDiagnosis, DifferentialEnzyme InhibitorsFemaleGastroesophageal RefluxHumansLiverMiddle AgedOmeprazolePantoprazoleProton Pump InhibitorsSulfoxidesUltrasonography, Doppler, Duplex