Future microbiology · 2024
Antimicrobial activity of hydralazine against methicillin-resistant and methicillin-susceptible Staphylococcus aureus.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Stefany Aires do Nascimento Francisca B, do Amaral Valente Sá Lívia Gurgel, de Andrade Neto João B, da Silva Lisandra Juvêncio, Rodrigues Daniel Sampaio, de Farias Cabral Vitória P, Barbosa Amanda Dias, Almeida Moreira Lara E, Braga Vasconcelos Camille R, Cavalcanti Bruno Coêlho, França Rios Maria E, Silva Jacilene, Marinho Emmanuel Silva, Dos Santos Helcio Silva, de Mesquita Jacó Rl, Pinto Lobo Marina Duarte, de Moraes Manoel Odorico, Nobre Júnior Hélio V, da Silva Cecília Rocha
Аннотация
Background: Staphylococcus aureus is a human pathogen responsible for high mortality rates. The development of new antimicrobials is urgent. Materials & methods: The authors evaluated the activity of hydralazine along with its synergism with other drugs and action on biofilms. With regard to action mechanisms, the authors evaluated cell viability, DNA damage and molecular docking. Results: MIC and minimum bactericidal concentration values ranged from 128 to 2048 μg/ml. There was synergism with oxacillin (50%) and vancomycin (25%). Hydralazine reduced the viability of biofilms by 50%. After exposure to hydralazine 2× MIC, 58.78% of the cells were unviable, 62.07% were TUNEL positive and 27.03% presented damage in the comet assay (p < 0.05). Hydralazine showed affinity for DNA gyrase and TyrRS. Conclusion: Hydralazine is a potential antibacterial.