Endocrine, metabolic & immune disorders drug targets · 2020
Diagnostic Approach to the Patients with Suspected Primary Immunodeficiency.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tavakol Marzieh, Jamee Mahnaz, Azizi Gholamreza, Sadri Homa, Bagheri Yasser, Zaki-Dizaji Majid, Mahdavi Fatemeh Sadat, Jadidi-Niaragh Farhad, Tajfirooz Sanaz, Kamali Ali N, Aghamahdi Fatemeh, Noorian Shahab, Kojidi Habibeh Taghavi, Mosavian Mehdi, Matani Rahman, Dolatshahi Elahe, Porrostami Kumars, Elahimehr Nasrin, Fatemi-Abhari Marzie, Sharifi Laleh, Arjmand Reza, Haghi Sabahat, Zainaldain Hamed, Yazdani Reza, Shaghaghi Mohammadreza, Abolhassani Hassan, Aghamohammadi Asghar
Аннотация
BACKGROUND AND OBJECTIVE: Primary immunodeficiency diseases (PIDs) are a group of more than 350 disorders affecting distinct components of the innate and adaptive immune systems. In this review, the classic and advanced stepwise approach towards the diagnosis of PIDs are simplified and explained in detail.
RESULTS: Susceptibility to recurrent infections is the main hallmark of almost all PIDs. However, noninfectious complications attributable to immune dysregulation presenting with lymphoproliferative and/or autoimmune disorders are not uncommon. Moreover, PIDs could be associated with misleading presentations including allergic manifestations, enteropathies, and malignancies.
CONCLUSION: Timely diagnosis is the most essential element in improving outcome and reducing the morbidity and mortality in PIDs. This wouldn't be possible unless the physicians keep the diagnosis of PID in mind and be sufficiently aware of the approach to these patients.
RESULTS: Susceptibility to recurrent infections is the main hallmark of almost all PIDs. However, noninfectious complications attributable to immune dysregulation presenting with lymphoproliferative and/or autoimmune disorders are not uncommon. Moreover, PIDs could be associated with misleading presentations including allergic manifestations, enteropathies, and malignancies.
CONCLUSION: Timely diagnosis is the most essential element in improving outcome and reducing the morbidity and mortality in PIDs. This wouldn't be possible unless the physicians keep the diagnosis of PID in mind and be sufficiently aware of the approach to these patients.