Medizinische Klinik (Munich, Germany : 1983) · 2007
[Leydig cell tumor as a cause of hirsutism in a postmenopausal woman].
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Matuszczyk Anna, Petersenn Stephan, Lahner Harald, Haude Michael, Veit Patrick, Becker Jan U, Kimmig Rainer, Bockisch Andreas, Mann Klaus
Аннотация
BACKGROUND: Hirsutism or virilization in postmenopausal women may be due to increased testosterone levels caused by an androgen-secreting tumor. The preoperative localization of small ovarian or adrenal androgen-secreting tumors is difficult.
CASE REPORT: A 61-year-old, postmenopausal woman presented with progressive hirsutism and deepening of voice over the last 9 years. Serum testosterone was very high (almost 30 nmol/l). Computed tomographic (CT) scans of the adrenals and ultrasonography of the pelvis were negative. Selective catheterization and [(18)F]FDG-PET/CT investigation raised the suspicion of an androgen-secreting tumor of the right ovary. Oophorectomy was performed, and a Leydig cell tumor of the right ovary was confirmed on histological examination.
CONCLUSION: Selective catheterization and [(18)F]FDG-PET investigation may aid the detection of androgen-secreting tumors.
CASE REPORT: A 61-year-old, postmenopausal woman presented with progressive hirsutism and deepening of voice over the last 9 years. Serum testosterone was very high (almost 30 nmol/l). Computed tomographic (CT) scans of the adrenals and ultrasonography of the pelvis were negative. Selective catheterization and [(18)F]FDG-PET/CT investigation raised the suspicion of an androgen-secreting tumor of the right ovary. Oophorectomy was performed, and a Leydig cell tumor of the right ovary was confirmed on histological examination.
CONCLUSION: Selective catheterization and [(18)F]FDG-PET investigation may aid the detection of androgen-secreting tumors.