Decompressive surgery in cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia.
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Krzywicka Katarzyna, Aguiar de Sousa Diana, Cordonnier Charlotte, Bode Felix J, Field Thalia S, Michalski Dominik, Pelz Johann, Skjelland Mona, Wiedmann Markus, Zimmermann Julian, Wittstock Matthias, Zanotti Bruno, Ciccone Alfonso, Bandettini di Poggio Monica, Borhani-Haghighi Afshin, Chatterton Sophie, Aujayeb Avinash, Devroye Annemie, Dizonno Vanessa, Geeraerts Thomas, Giammello Fabrizio, Günther Albrecht, Ichaporia Nasli R, Kleinig Timothy, Kristoffersen Espen S, Lemmens Robin, De Maistre Emmanuel, Mirzaasgari Zahra, Payen Jean-Francois, Putaala Jukka, Petruzzellis Marco, Raposo Nicolas, Sadeghi-Hokmabadi Elyar, Schoenenberger Silvia, Umaiorubahan Meenakshisundaram, Sylaja Padmavathy N, van de Munckhof Anita, Sánchez van Kammen Mayte, Lindgren Erik, Jood Katarina, Scutelnic Adrian, Heldner Mirjam R, Poli Sven, Kruip Marieke J H A, Arauz Antonio, Conforto Adriana B, Aaron Sanjith, Middeldorp Saskia, Tatlisumak Turgut, Arnold Marcel, Coutinho Jonathan M, Ferro José M, Cerebral Venous Sinus Thrombosis with Thrombocytopenia Syndrome Study Group
Аннотация
METHODS: Data from an ongoing international registry of patients who developed CVST within 28 days of SARS-CoV-2 vaccination, reported between 29 March 2021 and 10 May 2022, were used. Definite, probable and possible VITT cases, as defined by Pavord et al. (N Engl J Med 2021; 385: 1680-1689), were included.
RESULTS: Decompressive surgery was performed in 34/128 (27%) patients with CVST-VITT. In-hospital mortality was 22/34 (65%) in the surgical and 27/94 (29%) in the non-surgical group (p < 0.001). In all surgical cases, the cause of death was brain herniation. The highest mortality rates were found amongst patients with preoperative coma (17/18, 94% vs. 4/14, 29% in the non-comatose; p < 0.001) and bilaterally absent pupillary reflexes (7/7, 100% vs. 6/9, 67% with unilaterally reactive pupil, and 4/11, 36% with bilaterally reactive pupils; p = 0.023). Postoperative imaging revealed worsening of index haemorrhagic lesion in 19 (70%) patients and new haemorrhagic lesions in 16 (59%) patients. At a median follow-up of 6 months, 8/10 of surgical CVST-VITT who survived admission were functionally independent.
CONCLUSIONS: Almost two-thirds of surgical CVST-VITT patients died during hospital admission. Preoperative coma and bilateral absence of pupillary responses were associated with higher mortality rates. Survivors often achieved functional independence.