Ifosfamide-induced Catatonia - A Rare Presentation and Review of Ifosfamide-induced Central Nervous System Toxicity Along With Therapeutic Approaches.

BACKGROUND/AIM: Ifosfamide is a well-known chemotherapeutic agent used to treat various cancer types but is associated with central nervous system toxicity, termed ifosfamide-induced encephalopathy (IIE). Rarely, this toxicity manifests as catatonia.

CASE REPORT: We present the case of a 61-year-old woman with diffuse large B-cell lymphoma who developed profound catatonia after ifosfamide infusion. Her symptoms resolved completely following a single intravenous dose of lorazepam.

CONCLUSION

This case underscores the importance of recognizing catatonia as a manifestation of IIE and supports the use of lorazepam as both a diagnostic and therapeutic intervention.