Different dexmedetomidine combinations with sevoflurane, ketamine, or propofol lead to varying clinical and laboratory outcomes in rabbits.

OBJECTIVE

To compare the clinical and laboratory effects of dexmedetomidine + ketamine + sevoflurane (group 1), dexmedetomidine + propofol + sevoflurane (group 2), and dexmedetomidine + total IV propofol (group 3) anesthesia protocols and to introduce a safe anesthesia protocol to the literature and clinical practice.

METHODS

New Zealand white rabbits, which were preclinically examined and determined to be healthy, were included in the study. In accordance with the study protocol, the rabbits were randomly assigned to three different groups, demonstrating that the study was structured as a randomized controlled experimental trial comparing three anesthetic protocols.

RESULTS

A total of 24 rabbits (12 male, 12 female) were randomly divided into 3 different groups of 4 females and 4 males/group. Regarding vital signs, a decrease in pulse, respiration, and body temperature was observed in all groups. The difference in blood gas values between the groups was significant. Regarding hemogram parameters, similar effects were observed in all groups. A significant difference in glucose, AST, and albumin values related to biochemical parameters was identified.

CONCLUSIONS

All of the anesthesia protocols employed in this experimental study induced adequate anesthesia in rabbits without resulting in any serious complications or mortality.

CLINICAL RELEVANCE: These findings may assist in selecting anesthetic protocols in rabbits by balancing intraoperative stability and quality of recovery. The results are applicable to both clinical and experimental veterinary settings.