sc-ChromAging: A Single-Cell Chromatin Accessibility-based Clock Decodes Cell-Type-Specific Epigenetic Aging Trajectories.

sc-ChromAging, a chromatin accessibility-based aging clock, was developed using single-cell ATAC-seq from 401 Chinese individuals. It identified CD4⁺ naive T cells as the most accurate predictors of age. This clock linked immune aging with pathways in inflammation, infection, and tumor susceptibility, and connecting chromatin changes to plasma metabolites like triacylglycerols.