Zhongguo shi yan xue ye xue za zhi · 2024
[Clinical Analysis of CD4+CD8- T-Cell Large Granular Lymphocytic[JP] Leukemia].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод пока не подготовлен
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Chang Xiang-Xiang, Sun Shang-Biao, Li Yu-Wen, Wang Miao, Zhu Yan-Qing
Аннотация
OBJECTIVE: To investigate the clinical characteristics and treatment of patients with CD4+CD8- T-cell large granular lymphocytic leukemia (T-LGLL).
METHODS: The clinical manifestations, diagnosis and treatment of 1 case of CD4+CD8- T-LGLL patient were reported, and relevant literatures were reviewed.
RESULTS: The patient was a 70-year-old woman with slow clinical progress, mainly manifested by thrombocytopenia and myelodysplasia. The blood smear was mainly composed of large granular lymphocytes. Immunotyping and T-cell receptor gene rearrangement analysis showed that it was in line with T-LGLL. Partial remission(PR) was achieved through the treatment of cyclophosphamide(50 mg/d) combined with prednisone(gradually reduced and stopped later).
CONCLUSION: CD4+CD8- T-LGLL is very rare in clinical practice, and its clinical manifestations are different from those of CD4-CD8+ T-LGLL.
METHODS: The clinical manifestations, diagnosis and treatment of 1 case of CD4+CD8- T-LGLL patient were reported, and relevant literatures were reviewed.
RESULTS: The patient was a 70-year-old woman with slow clinical progress, mainly manifested by thrombocytopenia and myelodysplasia. The blood smear was mainly composed of large granular lymphocytes. Immunotyping and T-cell receptor gene rearrangement analysis showed that it was in line with T-LGLL. Partial remission(PR) was achieved through the treatment of cyclophosphamide(50 mg/d) combined with prednisone(gradually reduced and stopped later).
CONCLUSION: CD4+CD8- T-LGLL is very rare in clinical practice, and its clinical manifestations are different from those of CD4-CD8+ T-LGLL.