Studying the Influence of Ischemic Liver Damage on the Pharmacokinetics of a Phenolic Antioxidant.

A new approach has been developed to study the pharmacokinetics of 2,6-diisobornyl-4-methylphenol, a phenolic antioxidant, after intragastric administration at a dose of 10 mg/kg to male Wistar rats with ischemia/reperfusion liver injury. The control group consisted of rats without pathology. A catheter previously implanted into the jugular vein of the animals, allowed repeated blood sampling and monitoring of the pharmacokinetic profile of the substance in each animal. Pharmacokinetic studies usually involve healthy animals, but the ischemia/reperfusion injury of the liver disrupted its functions, potentially altering drug metabolism and pharmacokinetics. Analysis of actual blood plasma samples confirmed the effectiveness of the proposed approach: changes in the pharmacokinetics of the phenolic antioxidant were revealed during liver ischemia/reperfusion injury in rats.