Dermatology (Basel, Switzerland) · 2001
Pentoxifylline attenuates UVB-induced cutaneous erythema.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lowitt M H
Аннотация
BACKGROUND: The mechanism for ultraviolet-B (UVB)-associated cutaneous erythema may involve production of tumor necrosis factor alpha (TNF-alpha). Pentoxifylline inhibits TNF-alpha production.
OBJECTIVE: To assess the effect of oral pentoxifylline on UVB-induced erythema in humans.
METHODS: Baseline minimum erythema doses (MEDs) for UVB were measured. Subjects received pentoxifylline 400 mg orally every 8 h for 4 doses. MED assays were repeated 2 h after the last dose of pentoxifylline. Pre- and posttreatment MED results were assessed by the paired t test.
RESULTS: Oral administration of pentoxifylline to 7 normal adults elevated the MED for UVB in all 7 individuals.
CONCLUSION: Pentoxifylline may diminish the cutaneous sunburn response to UVB radiation when it is administered prior to ultraviolet exposure.
OBJECTIVE: To assess the effect of oral pentoxifylline on UVB-induced erythema in humans.
METHODS: Baseline minimum erythema doses (MEDs) for UVB were measured. Subjects received pentoxifylline 400 mg orally every 8 h for 4 doses. MED assays were repeated 2 h after the last dose of pentoxifylline. Pre- and posttreatment MED results were assessed by the paired t test.
RESULTS: Oral administration of pentoxifylline to 7 normal adults elevated the MED for UVB in all 7 individuals.
CONCLUSION: Pentoxifylline may diminish the cutaneous sunburn response to UVB radiation when it is administered prior to ultraviolet exposure.