Clinica chimica acta; international journal of clinical chemistry · 2016
Preanalytics: The (in-)stability of volatile POCT parameters and the homogeneity of blood in syringes at the market.
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Gruber Michael A, Felbermeir Stefan, Lindner Regina, Kieninger Martin
Аннотация
BACKGROUND: In between calibrations, quality controls and so on reduce the availability of blood gas analyzers. Despite the intended urgency of the measurements, these inhibitory circumstances cause delays of measurements. The comparison of changes (primarily PO2 and PCO2, secondarily ctHb) in syringes from different suppliers and the embedding into guideline ranges are the objectives of this study.
METHODS: Five matrices were tonometered at two levels within the German guideline (RiLi-BAEK) controlled range. Matrices were aspired into each syringe and blood gas analysis accomplished after 0 to 30min. The procedure was repeated 5 to 8-fold for the gas concentrations and every condition which consisted of syringe type (7), matrices (5) and time delay (7).
RESULTS: Syringes produce almost identical effects on partial pressures during the 30min observation period. Initial fast changes arise when partial pressure (PP) differs widely from the atmospheric pressure and are followed by diffusion, gas production or consumption and ctHb depending effects.
CONCLUSIONS: Only normal arterial blood gases without "atmospheric pollution" are not affected by the syringe materials within 30min. The homogeneity of a de-aerated and capped ICU-patients' sample is hardly to be provided after more than 10min of resting without mechanical assistance.
METHODS: Five matrices were tonometered at two levels within the German guideline (RiLi-BAEK) controlled range. Matrices were aspired into each syringe and blood gas analysis accomplished after 0 to 30min. The procedure was repeated 5 to 8-fold for the gas concentrations and every condition which consisted of syringe type (7), matrices (5) and time delay (7).
RESULTS: Syringes produce almost identical effects on partial pressures during the 30min observation period. Initial fast changes arise when partial pressure (PP) differs widely from the atmospheric pressure and are followed by diffusion, gas production or consumption and ctHb depending effects.
CONCLUSIONS: Only normal arterial blood gases without "atmospheric pollution" are not affected by the syringe materials within 30min. The homogeneity of a de-aerated and capped ICU-patients' sample is hardly to be provided after more than 10min of resting without mechanical assistance.