Microorganisms · 2023
Antibodies to Combat Fungal Infections: Development Strategies and Progress.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Rabaan Ali A, Alfaraj Amal H, Alshengeti Amer, Alawfi Abdulsalam, Alwarthan Sara, Alhajri Mashael, Al-Najjar Amal H, Al Fares Mona A, Najim Mustafa A, Almuthree Souad A, AlShurbaji Sultan T, Alofi Fadwa S, AlShehail Bashayer M, AlYuosof Buthina, Alynbiawi Ahlam, Alzayer Suha A, Al Kaabi Nawal, Abduljabbar Wesam A, Bukhary Zakiyah A, Bueid Ahmed S
Аннотация
The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specific (such as lymphocyte) cell-mediated immunity and stop or aid in eradicating fungus infections. The ability of antibodies to defend against fungi has been demonstrated by using monoclonal antibody technology to reconsider the function of antibody immunity. The next step is to develop vaccines that induce protective antibody immunity and to comprehend the mechanisms through which antibodies mediate protective effects against fungus.