Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology · 2014
[Topics of neuromyelitis optica].
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Miyamoto Katsuichi
Аннотация
Neuromyelitis optica (NMO) has been revealed the difference in the pathology of multiple sclerosis since the anti-aquaporin 4 (AQP4) antibody associated with NMO has been found. The clinical epidemiological study has been reviewed, NMO-related patient number in Japan is estimated to be about 4400 people. The antibody-positive patients against myelin-oligodendrocyte glycoprotein (MOG) are present in anti-AQP4 antibody-negative NMO patients. These patients have a characteristic with high frequency of optic neuritis and good response to therapy. In addition, by research in recent years, a new treatment such as anti-IL-6 therapy or anti-complement therapy has been attempted to NMO.
Предметные рубрики MeSH
Antibodies, Monoclonal, HumanizedAntibodies, Monoclonal, Murine-DerivedAquaporin 4AutoantibodiesClinical Trials as TopicDrug Therapy, CombinationFemaleHumansImmunosuppressive AgentsJapanMaleMethylprednisoloneMolecular Targeted TherapyNeuromyelitis OpticaPrednisolonePulse Therapy, DrugRecurrenceRituximabSex Factors