Clinical cardiology · 2023
Maximal functional capacity in subjects with isolated left bundle branch block: A pilot study.
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Palau Patricia, Mendez Jose, Santas Enrique, Núñez Julio, López Laura, Briatore Antonio, Domínguez Eloy
Аннотация
BACKGROUND: Left bundle branch block (LBBB) has been commonly associated with adverse cardiovascular (CV) events, but the effect of an isolated LBBB on maximal functional capacity is not well characterized.
OBJECTIVE: To evaluate maximal functional capacity in adults with isolated LBBB and compare it to healthy population-derived predicted values (adjusted for sex, age, weight, and height).
METHODS: This descriptive pilot study included subjects with isolated LBBB derived from outpatient clinics of two academic hospitals. All subjects underwent maximal cardiopulmonary exercise testing (CPET) and a Global Physical Activity Questionnaire (GPAQ). The primary outcome was to evaluate maximal functional capacity according to population-derived predicted values of peak oxygen consumption (peakVO2 ): pp-peakVO2 . The secondary outcome was to report adverse CV events (CV deaths or hospitalizations) at follow-up.
RESULTS: A total of 27 (18 women and 9 men) participants were included. The median (interquartile range) age of the sample and time to screening from the first LBBB diagnosis were 62 (51-71) and 3.4 (1.1-8.4) years, respectively. The results of the GPAQ score showed that 19 patients were highly active, and 8 were moderately active. The median of peakVO2 and pp-peakVO2 were 19.3 (15-22.5) ml/kg/min and 88% (79.3%-104.4%), respectively. There were no adverse CV events at a median follow-up after CPET of 3.1 (2.7-3.4) years.
CONCLUSION: In this pilot study, adults with isolated LBBB showed reduced maximal functional capacity, despite the absence of cardiac disease and a baseline moderate to highly active lifestyle.
OBJECTIVE: To evaluate maximal functional capacity in adults with isolated LBBB and compare it to healthy population-derived predicted values (adjusted for sex, age, weight, and height).
METHODS: This descriptive pilot study included subjects with isolated LBBB derived from outpatient clinics of two academic hospitals. All subjects underwent maximal cardiopulmonary exercise testing (CPET) and a Global Physical Activity Questionnaire (GPAQ). The primary outcome was to evaluate maximal functional capacity according to population-derived predicted values of peak oxygen consumption (peakVO2 ): pp-peakVO2 . The secondary outcome was to report adverse CV events (CV deaths or hospitalizations) at follow-up.
RESULTS: A total of 27 (18 women and 9 men) participants were included. The median (interquartile range) age of the sample and time to screening from the first LBBB diagnosis were 62 (51-71) and 3.4 (1.1-8.4) years, respectively. The results of the GPAQ score showed that 19 patients were highly active, and 8 were moderately active. The median of peakVO2 and pp-peakVO2 were 19.3 (15-22.5) ml/kg/min and 88% (79.3%-104.4%), respectively. There were no adverse CV events at a median follow-up after CPET of 3.1 (2.7-3.4) years.
CONCLUSION: In this pilot study, adults with isolated LBBB showed reduced maximal functional capacity, despite the absence of cardiac disease and a baseline moderate to highly active lifestyle.