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Nature genetics · 2019

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Watson Hunna J, Yilmaz Zeynep, Thornton Laura M, Hübel Christopher, Coleman Jonathan R I, Gaspar Héléna A, Bryois Julien, Hinney Anke, Leppä Virpi M, Mattheisen Manuel, Medland Sarah E, Ripke Stephan, Yao Shuyang, Giusti-Rodríguez Paola, Anorexia Nervosa Genetics Initiative, Hanscombe Ken B, Purves Kirstin L, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Adan Roger A H, Alfredsson Lars, Ando Tetsuya, Andreassen Ole A, Baker Jessica H, Berrettini Wade H, Boehm Ilka, Boni Claudette, Perica Vesna Boraska, Buehren Katharina, Burghardt Roland, Cassina Matteo, Cichon Sven, Clementi Maurizio, Cone Roger D, Courtet Philippe, Crow Scott, Crowley James J, Danner Unna N, Davis Oliver S P, de Zwaan Martina, Dedoussis George, Degortes Daniela, DeSocio Janiece E, Dick Danielle M, Dikeos Dimitris, Dina Christian, Dmitrzak-Weglarz Monika, Docampo Elisa, Duncan Laramie E, Egberts Karin, Ehrlich Stefan, Escaramís Geòrgia, Esko Tõnu, Estivill Xavier, Farmer Anne, Favaro Angela, Fernández-Aranda Fernando, Fichter Manfred M, Fischer Krista, Föcker Manuel, Foretova Lenka, Forstner Andreas J, Forzan Monica, Franklin Christopher S, Gallinger Steven, Giegling Ina, Giuranna Johanna, Gonidakis Fragiskos, Gorwood Philip, Mayora Monica Gratacos, Guillaume Sébastien, Guo Yiran, Hakonarson Hakon, Hatzikotoulas Konstantinos, Hauser Joanna, Hebebrand Johannes, Helder Sietske G, Herms Stefan, Herpertz-Dahlmann Beate, Herzog Wolfgang, Huckins Laura M, Hudson James I, Imgart Hartmut, Inoko Hidetoshi, Janout Vladimir, Jiménez-Murcia Susana, Julià Antonio, Kalsi Gursharan, Kaminská Deborah, Kaprio Jaakko, Karhunen Leila, Karwautz Andreas, Kas Martien J H, Kennedy James L, Keski-Rahkonen Anna, Kiezebrink Kirsty, Kim Youl-Ri, Klareskog Lars, Klump Kelly L, Knudsen Gun Peggy S, La Via Maria C, Le Hellard Stephanie, Levitan Robert D, Li Dong, Lilenfeld Lisa, Lin Bochao Danae, Lissowska Jolanta, Luykx Jurjen, Magistretti Pierre J, Maj Mario, Mannik Katrin, Marsal Sara, Marshall Christian R, Mattingsdal Morten, McDevitt Sara, McGuffin Peter, Metspalu Andres, Meulenbelt Ingrid, Micali Nadia, Mitchell Karen, Monteleone Alessio Maria, Monteleone Palmiero, Munn-Chernoff Melissa A, Nacmias Benedetta, Navratilova Marie, Ntalla Ioanna, O'Toole Julie K, Ophoff Roel A, Padyukov Leonid, Palotie Aarno, Pantel Jacques, Papezova Hana, Pinto Dalila, Rabionet Raquel, Raevuori Anu, Ramoz Nicolas, Reichborn-Kjennerud Ted, Ricca Valdo, Ripatti Samuli, Ritschel Franziska, Roberts Marion, Rotondo Alessandro, Rujescu Dan, Rybakowski Filip, Santonastaso Paolo, Scherag André, Scherer Stephen W, Schmidt Ulrike, Schork Nicholas J, Schosser Alexandra, Seitz Jochen, Slachtova Lenka, Slagboom P Eline, Slof-Op 't Landt Margarita C T, Slopien Agnieszka, Sorbi Sandro, Świątkowska Beata, Szatkiewicz Jin P, Tachmazidou Ioanna, Tenconi Elena, Tortorella Alfonso, Tozzi Federica, Treasure Janet, Tsitsika Artemis, Tyszkiewicz-Nwafor Marta, Tziouvas Konstantinos, van Elburg Annemarie A, van Furth Eric F, Wagner Gudrun, Walton Esther, Widen Elisabeth, Zeggini Eleftheria, Zerwas Stephanie, Zipfel Stephan, Bergen Andrew W, Boden Joseph M, Brandt Harry, Crawford Steven, Halmi Katherine A, Horwood L John, Johnson Craig, Kaplan Allan S, Kaye Walter H, Mitchell James E, Olsen Catherine M, Pearson John F, Pedersen Nancy L, Strober Michael, Werge Thomas, Whiteman David C, Woodside D Blake, Stuber Garret D, Gordon Scott, Grove Jakob, Henders Anjali K, Juréus Anders, Kirk Katherine M, Larsen Janne T, Parker Richard, Petersen Liselotte, Jordan Jennifer, Kennedy Martin, Montgomery Grant W, Wade Tracey D, Birgegård Andreas, Lichtenstein Paul, Norring Claes, Landén Mikael, Martin Nicholas G, Mortensen Preben Bo, Sullivan Patrick F, Breen Gerome, Bulik Cynthia M

Аннотация

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты