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Nature genetics · 2018

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Giri Ayush, Hellwege Jacklyn N, Keaton Jacob M, Park Jihwan, Qiu Chengxiang, Warren Helen R, Torstenson Eric S, Kovesdy Csaba P, Sun Yan V, Wilson Otis D, Robinson-Cohen Cassianne, Roumie Christianne L, Chung Cecilia P, Birdwell Kelly A, Damrauer Scott M, DuVall Scott L, Klarin Derek, Cho Kelly, Wang Yu, Evangelou Evangelos, Cabrera Claudia P, Wain Louise V, Shrestha Rojesh, Mautz Brian S, Akwo Elvis A, Sargurupremraj Muralidharan, Debette Stéphanie, Boehnke Michael, Scott Laura J, Luan Jian'an, Zhao Jing-Hua, Willems Sara M, Thériault Sébastien, Shah Nabi, Oldmeadow Christopher, Almgren Peter, Li-Gao Ruifang, Verweij Niek, Boutin Thibaud S, Mangino Massimo, Ntalla Ioanna, Feofanova Elena, Surendran Praveen, Cook James P, Karthikeyan Savita, Lahrouchi Najim, Liu Chunyu, Sepúlveda Nuno, Richardson Tom G, Kraja Aldi, Amouyel Philippe, Farrall Martin, Poulter Neil R, Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Laakso Markku, Zeggini Eleftheria, Sever Peter, Scott Robert A, Langenberg Claudia, Wareham Nicholas J, Conen David, Palmer Colin Neil Alexander, Attia John, Chasman Daniel I, Ridker Paul M, Melander Olle, Mook-Kanamori Dennis Owen, Harst Pim van der, Cucca Francesco, Schlessinger David, Hayward Caroline, Spector Tim D, Jarvelin Marjo-Riitta, Hennig Branwen J, Timpson Nicholas J, Wei Wei-Qi, Smith Joshua C, Xu Yaomin, Matheny Michael E, Siew Edward E, Lindgren Cecilia, Herzig Karl-Heinz, Dedoussis George, Denny Joshua C, Psaty Bruce M, Howson Joanna M M, Munroe Patricia B, Newton-Cheh Christopher, Caulfield Mark J, Elliott Paul, Gaziano J Michael, Concato John, Wilson Peter W F, Tsao Philip S, Velez Edwards Digna R, Susztak Katalin, Million Veteran Program, O'Donnell Christopher J, Hung Adriana M, Edwards Todd L

Аннотация

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты