Head and neck pathology · 2025
Mucoepidermoid Carcinoma Associated with an Intercalated Duct Lesion: Precursor or Coincidence?
СтатьяКлинический случайНазвание и аннотация: Перевод пока не подготовлен
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Goldfaden Joshua S, Kim Seungwon, Seethala Raja R
Аннотация
BACKGROUND: Mucoepidermoid carcinoma (MEC) typically occurs in isolation. We report an unusual case of MEC coexisting with an intercalated duct lesion (IDL), both harboring MAML2 rearrangements.
CASE PRESENTATION: An 82-year-old male with a left parotid mass underwent superficial parotidectomy.
METHODS: Microscopic examination of immunohistochemical stains and fluorescence in situ hybridization (FISH) studies were performed.
RESULTS: The parotid demonstrated an intermediate grade MEC and an adjacent IDL with the typical abluminal ΔNp63 (p40) and ductal SOX-10 immunopositivity, but absent LEF-1 and nuclear β-catenin staining. FISH confirmed MAML2 rearrangements in both lesions.
CONCLUSION: This case expands the spectrum of IDL-associated tumors and suggests IDLs may serve as MEC precursors.
CASE PRESENTATION: An 82-year-old male with a left parotid mass underwent superficial parotidectomy.
METHODS: Microscopic examination of immunohistochemical stains and fluorescence in situ hybridization (FISH) studies were performed.
RESULTS: The parotid demonstrated an intermediate grade MEC and an adjacent IDL with the typical abluminal ΔNp63 (p40) and ductal SOX-10 immunopositivity, but absent LEF-1 and nuclear β-catenin staining. FISH confirmed MAML2 rearrangements in both lesions.
CONCLUSION: This case expands the spectrum of IDL-associated tumors and suggests IDLs may serve as MEC precursors.