QJM : monthly journal of the Association of Physicians · 2020
Paraneoplastic sarcoidosis: a review.
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Herron M, Chong S G, Gleeson L, Nicholson S, Fahy R J
Аннотация
BACKGROUND: Sarcoidosis is occasionally seen in association with malignancy, both at the time of cancer diagnosis or during follow up.
AIM: The purpose of this study is to identify patients with paraneoplastic sarcoid, their associated malignancies and disease characteristics.
METHODS: We identified 289 patients diagnosed histologically with sarcoidosis over a 6-year period in one centre, from 2010 to 2016. Fifty of these patients had a prior or concomitant diagnosis of cancer.
RESULTS: 17.3% of sarcoid cases had an associated malignancy. The most common malignancies were Gastrointestinal (20%), Haematological (18%), Lung (12%), Gynaecological (12%) and Head and Neck cancer (12%). 74% of sarcoid cases had pulmonary disease with sarcoid diagnostic tissue obtained most frequently via endobronchial ultrasound fine needle aspiration (68%). Most sarcoid cases (66%) were diagnosed within the first year of their malignancy diagnosis.
DISCUSSION: Careful consideration needs to be given to the possibility that potential cancer recurrences suspected on imaging studies may indeed be sarcoid reactions.
AIM: The purpose of this study is to identify patients with paraneoplastic sarcoid, their associated malignancies and disease characteristics.
METHODS: We identified 289 patients diagnosed histologically with sarcoidosis over a 6-year period in one centre, from 2010 to 2016. Fifty of these patients had a prior or concomitant diagnosis of cancer.
RESULTS: 17.3% of sarcoid cases had an associated malignancy. The most common malignancies were Gastrointestinal (20%), Haematological (18%), Lung (12%), Gynaecological (12%) and Head and Neck cancer (12%). 74% of sarcoid cases had pulmonary disease with sarcoid diagnostic tissue obtained most frequently via endobronchial ultrasound fine needle aspiration (68%). Most sarcoid cases (66%) were diagnosed within the first year of their malignancy diagnosis.
DISCUSSION: Careful consideration needs to be given to the possibility that potential cancer recurrences suspected on imaging studies may indeed be sarcoid reactions.