Journal of neuroimmunology · 2007
Differential cerebro spinal fluid proteome investigation of Leber hereditary optic neuropathy (LHON) and multiple sclerosis.
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D'Aguanno Simona, Barassi Alessandra, Lupisella Santina, d'eril Gianlodovico Melzi, Del Boccio Piero, Pieragostino Damiana, Pallotti Francesco, Carelli Valerio, Valentino Maria Lucia, Liguori Rocco, Avoni Patrizia, Bernardini Sergio, Gambi Domenico, Urbani Andrea, Federici Giorgio
Аннотация
Leber's hereditary optic neuropathy (LHON) is a genetic disease leading to the loss of central vision and optic nerve atrophy. The existence of occasional cases of LHON patients developing a Multiple Sclerosis (MS)-like illness and the hypothesis that mtDNA variants may be involved in MS suggest the possibility of some common molecular mechanisms linking the two diseases. We have pursued a comparative proteomics approach on cerebrospinal fluid (CSF) samples from LHON and MS patients, as well as healthy donors by employing 2-DE gel separations coupled to MALDI-TOF-MS and nLC-MS/MS investigations. 7 protein spots showed significant differential distribution among the three groups. Both CSF of LHON or MS patients are characterized by lower level of transthyretin dimer adduct while a specific up regulation of Apo A-IV was detected in LHON CSF.