Archivos de la Sociedad Espanola de Oftalmologia · 2007
[Response to idebenone and multivitamin therapy in Leber's hereditary optic neuropathy].
Клинический случайАннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Barnils N, Mesa E, Muñoz S, Ferrer-Artola A, Arruga J
Аннотация
OBJECTIVE: To ascertain the efficacy of idebenone and multivitamin treatment in Leber's hereditary optic neuropathy (LHON).
METHOD: Two patients diagnosed of unilateral LHON were treated with megadoses of idebenone, vitamin C and riboflavin for one year. They were examined clinically before, during and after treatment.
RESULTS: No improvement of visual function was observed. Despite the idebenone treatment, in both cases the second eye became involved.
CONCLUSIONS: Despite previous reports of visual recovery with idebenone in patients with LHON, our experience shows that an effective treatment for Leber's disease remains to be found.
METHOD: Two patients diagnosed of unilateral LHON were treated with megadoses of idebenone, vitamin C and riboflavin for one year. They were examined clinically before, during and after treatment.
RESULTS: No improvement of visual function was observed. Despite the idebenone treatment, in both cases the second eye became involved.
CONCLUSIONS: Despite previous reports of visual recovery with idebenone in patients with LHON, our experience shows that an effective treatment for Leber's disease remains to be found.