Chemotherapy · 2006
Insulin-like growth factor delivery across the blood-brain barrier. Potential use of IGF-1 as a drug in child neurology.
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Riikonen Raili
Аннотация
BACKGROUND: Recent data indicate that insulin-like growth factor-1 (IGF-1) can cross the blood-brain barrier when bound to binding proteins. IGF-1 is very important for early brain development, myelination and survival of cerebellar neurons. It is antiapoptotic and is important for synaptic development. The aim of this study was to identify neurological conditions with low CNS IGF-1.
METHODS: Levels of CSF IGF-1 were determined by radio-immunoassay (Mediagnost, Tubingen, Germany).
RESULTS: Levels of CSF IGF-1 were low in some progressive diseases of white matter and the cerebellum. In some other diseases not involving cerebellum or white matter, CSF IGF-1 was normal.
CONCLUSIONS: Our findings might pave the way for rational therapy in patients with neurodegeneration. Patients with low CNS IGF-1 might be candidates for IGF-1 therapy.
METHODS: Levels of CSF IGF-1 were determined by radio-immunoassay (Mediagnost, Tubingen, Germany).
RESULTS: Levels of CSF IGF-1 were low in some progressive diseases of white matter and the cerebellum. In some other diseases not involving cerebellum or white matter, CSF IGF-1 was normal.
CONCLUSIONS: Our findings might pave the way for rational therapy in patients with neurodegeneration. Patients with low CNS IGF-1 might be candidates for IGF-1 therapy.
Предметные рубрики MeSH
Autistic DisorderBlood-Brain BarrierBrain DiseasesCase-Control StudiesCentral Nervous SystemDisease ProgressionHeredodegenerative Disorders, Nervous SystemHumansInsulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IOptic AtrophyPrecursor Cell Lymphoblastic Leukemia-LymphomaRadioimmunoassay