Journal of clinical and experimental neuropsychology · 2018
Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Broster Lucas S, Li Juan, Wagner Benjamin, Smith Charles D, Jicha Gregory A, Schmitt Frederick A, Munro Nancy, Haney Ryan H, Jiang Yang
Аннотация
OBJECTIVE: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex.
METHOD: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects.
RESULTS: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect.
CONCLUSION: Visual cortex may play a role in maintained repetition effects in persons with early AD.
METHOD: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects.
RESULTS: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect.
CONCLUSION: Visual cortex may play a role in maintained repetition effects in persons with early AD.