Role of capsule endoscopy in alarm features and non-responsive celiac disease: A European multicenter study.
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Perez-Cuadrado-Robles Enrique, Lujan-Sanchis Marisol, Elli Luca, Juanmartinena-Fernandez Jose-Francisco, Garcıa-Lledo Javier, Ruano-Dıaz Lucıa, Egea-Valenzuela Juan, Jimenez-Garcıa Victoria-Alejandra, Arguelles-Arias Federico, Juan-Acosta Mileidis San, Carretero-Ribon Cristina, Alonso-Lazaro Noelia, Rosa Bruno, Sanchez-Ceballos Francisco, Lopez-Higueras Antonio, Fernandez-Urien-Sainz Ignacio, Branchi Federica, Valle-Muñoz Julio, Borque-Barrera Pilar, Gonzalez-Vazquez Santiago, Pons-Beltran Vicente, Xavier Sofıa, Gonzalez-Suarez Begona, Herrerıas-Gutierrez Juan-Manuel, Perez-Cuadrado-Martınez Enrique, Sempere-Garcıa-Arguelles Javier, Enteroscopy and Capsule Endoscopy Spanish Society Group of the Spanish Society of Digestive Endoscopy (SEED)
Аннотация
METHODS: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed.
RESULTS: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications.
CONCLUSION: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.