High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
de Queiroz Natércia Neves Marques, de Melo Franciane Trindade Cunha, de Souza Resende Fabrício, Janaú Luísa Corrêa, de Souza Neto Norberto Jorge Kzan, de Lemos Manuela Nascimento, de Oliveira Maria Clara Neres Iunes, de Alcântara Angélica Leite, de Moraes Lorena Vilhena, da Mota Queiroz Apolone, de Souza Ícaro José Araújo, Said Nivin Mazen, Dos Santos Márcia Costa, de Souza D'Albuquerque Silva Lilian, Motta Ana Regina Bastos, de Sá Oliveira Dos Reis Melissa, Lobato Isabel Jane Campos, de Figueiredo Priscila Boaventura Barbosa, de Souza Ana Carolina Contente Braga, Freire Piani Pedro Paulo, Felício Karem Miléo, Abrahão Neto João Felício, Felício João Soares
Аннотация
OBJECTIVE: The aim of this study was to evaluate high-dose vitamin D supplementation effects on blood pressure of normotensive patients with diabetes mellitus 1 (DM1) patients by 24-hour ambulatory blood pressure monitoring (ABPM).
METHODS: We performed a clinical trial including 35 DM1 normotensive patients, who received doses of 4,000 or 10,000 IU/day of cholecalciferol for 12 weeks according to previous VD levels. They underwent 24-hour ABPM, along with glycated hemoglobin, creatine, lipids profile and PCRus dosage before and after VD supplementation.
RESULTS: We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs 112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in other pressoric markers. Besides, we noticed a relationship between levels of VD after supplementation and diastolic morning blood pressure (r= -0,4; p<0.05).
CONCLUSION: Our study suggests an association between supplementation of high doses of vitamin D and the reduction of morning blood pressure in normotensive DM1 patients.