Journal of thrombosis and thrombolysis · 2017
Retinal vein occlusion and paroxysmal nocturnal hemoglobinuria.
Клиническое исследованиеПисьмо в редакциюНазвание и аннотация: Перевод пока не подготовлен
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Sorigue Marc, Juncà Jordi, Orna Elisa, Romanic Nevena, Sarrate Edurne, Castellvi Jordi, Soler Montse, Rodríguez-Hernandez Ines, Feliu Evarist, Ruiz Susana
Аннотация
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder associated with increased risk for thrombosis and reduced life expectancy. Retinal vein occlusion (RVO) is a frequent cause of vision loss but its relationship with PNH has not been studied systematically. Patients followed up for RVO in our ophthalmology department were screened for the presence of a PNH clone in peripheral blood by means of flow cytometry. The presence of other well-documented risk factors for RVO was also analyzed. In a series of 110 patients (54 males, median age of 67) we found no evidence of PNH. Most patients (97/110) had cardiovascular risk factors and/or hyperhomocysteinemia (67/110). Inherited thrombophilias were rare (three confirmed cases). Therefore, PNH does not appear to play a role in the development of RVO. However, this finding does not necessarily apply to young patients and/or those with no conventional risk factors for RVO, due to the low number of patients in these subgroups in our population.