[Manifestations of painless myocardial ischemia in patients with chronic obstructive pulmonary disease].

Aim of the study was to investigate prevalence and special characteristics of manifestations of painless myocardial ischemia (PMI) in patients with chronic obstructive pulmonary disease (COPD) at exacerbation stage with various degree of severity and to assess risk of cardiovascular events in this group of patients. We carried out complex clinical-instrumental and laboratory examination of 54 patients with COPD. Examination included 24 hour Holter ECG monitoring, registration of parameters of pulmonary function, and endothelium dependent and independent vasoreactivity, determination of lipid spectrum, blood gases composition. We established that aggravation of degree of COPD severity was associated with increase of frequency of episodes of PMI and their total daily duration. During 12 months follow up incidence of cardiovascular events in the group of patients with episodes of PIM was 66.6%