International journal of cardiology · 2013
Carotid body removal for treatment of chronic systolic heart failure.
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Niewiński Piotr, Janczak Dariusz, Rucinski Artur, Jazwiec Przemyslaw, Sobotka Paul A, Engelman Zoar J, Fudim Marat, Tubek Stanislaw, Jankowska Ewa A, Banasiak Waldemar, Hart Emma C J, Paton Julian F R, Ponikowski Piotr
Аннотация
BACKGROUND: Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome.
METHODS AND RESULTS: We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.
CONCLUSIONS: Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821).
METHODS AND RESULTS: We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events.
CONCLUSIONS: Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure (NCT01653821).