Clinical and experimental nephrology · 2010
Successful treatment of HCV-related cryoglobulinemic glomerulonephritis with double-filtration plasmapheresis and interferon combination therapy.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Namba Tomoko, Shiba Rie, Yamamoto Takeshi, Hirai Yasuhiro, Moriwaki Takuma, Matsuda Jun, Kadoya Hiroyuki, Takeji Masanobu, Yamada Yukinori, Yoshihara Harumasa, Yamauchi Atsushi
Аннотация
A 67-year-old, hepatitis C virus (HCV)-positive woman was admitted to our hospital because of proteinuria and leg edema. Laboratory examination showed decreased serum albumin and complement activity and positive cryoglobulin. The HCV RNA genotype was 1b with high viral load. Kidney biopsy showed membranoproliferative glomerulonephritis (MPGN) with capillary deposition of C3, IgM, and IgG, indicating HCV-associated glomerulonephritis. In addition to interferon (IFN) therapy, double-filtration plasmapheresis (DFPP) was performed to reduce HCV RNA blood levels in the early stage of IFN therapy. This treatment greatly reduced the viral load and induced clinical remission of MPGN, suggesting that DFPP plus IFN combination therapy may represent a potentially effective modality for refractory-type HCV-associated glomerulonephritis.
Предметные рубрики MeSH
AgedAntiviral AgentsBiopsyCombined Modality TherapyCryoglobulinemiaDrug Therapy, CombinationEdemaFemaleGenotypeGlomerulonephritis, MembranoproliferativeHepacivirusHepatitis CHumansInterferon alpha-2Interferon-alphaKidneyPlasmapheresisPolyethylene GlycolsProteinuriaRNA, ViralRecombinant ProteinsRibavirinTime FactorsTreatment OutcomeViral Load