Aging & mental health · 2026
Association between anemia and cognitive dysfunction in the hypertensive older adults: a cross-sectional study.
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Luo Libo, He Jiamei, Liu Xiaoli, Zhuang Shaohui, Xiao Qingyu
Аннотация
OBJECTIVES: Using 2011-2014 National Health and Nutrition Examination Survey (NHANES) data, the research aims to explore the association of anemia and cognitive dysfunction in older patients with hypertension.
METHOD: The study included 2005 older participants aged ≥60 years. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning subtest, the Animal Fluency Test (AFT) and the Digit Symbol Substitution Test (DSST). Multivariate logistic regression analysis and a weighted restricted cubic spline (RCS) curve were employed to examine the potential association between hemoglobin levels and cognitive dysfunction.
RESULTS: Anemia was associated with higher odds of cognitive dysfunction in hypertensive older adults (OR = 1.663, 95% CI: 1.082-2.557, p = 0.022). Higher level of hemoglobin was associated with reduced odds of cognitive dysfunction (OR = 0.880, 95% CI: 0.782-0.991, p = 0.036). Hemoglobin levels below 13.67 g/dL were significantly associated with increased odds of cognitive impairment.
CONCLUSION: This study indicates the existence of an association between anemia and cognitive dysfunction among hypertensive older adults. Hemoglobin levels may serve as a predictor of cognitive decline, with 13.67g/dL as a potential threshold for intensive cognitive monitoring in high-risk older populations with hypertension.
METHOD: The study included 2005 older participants aged ≥60 years. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning subtest, the Animal Fluency Test (AFT) and the Digit Symbol Substitution Test (DSST). Multivariate logistic regression analysis and a weighted restricted cubic spline (RCS) curve were employed to examine the potential association between hemoglobin levels and cognitive dysfunction.
RESULTS: Anemia was associated with higher odds of cognitive dysfunction in hypertensive older adults (OR = 1.663, 95% CI: 1.082-2.557, p = 0.022). Higher level of hemoglobin was associated with reduced odds of cognitive dysfunction (OR = 0.880, 95% CI: 0.782-0.991, p = 0.036). Hemoglobin levels below 13.67 g/dL were significantly associated with increased odds of cognitive impairment.
CONCLUSION: This study indicates the existence of an association between anemia and cognitive dysfunction among hypertensive older adults. Hemoglobin levels may serve as a predictor of cognitive decline, with 13.67g/dL as a potential threshold for intensive cognitive monitoring in high-risk older populations with hypertension.