COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy).
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Ошибки и ограничения
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Martinelli-Boneschi Filippo, Colombo Antonio, Bresolin Nereo, Sessa Maria, Bassi Pietro, Grampa Giampiero, Magni Eugenio, Versino Maurizio, Ferrarese Carlo, Zarcone Davide, Albanese Alberto, Micieli Giuseppe, Zanferrari Carla, Cagnana Antonio, Ferrante Claudio, Zilioli Angelo, Locatelli Davide, Calloni Maria Vittoria, Delodovici Maria Luisa, Pozzato Mattia, Patisso Valerio, Bortolan Francesco, Foresti Camillo, Frigeni Barbara, Canella Stefania, Xhani Rubjona, Crabbio Massimo, Clemenzi Alessandro, Mauri Marco, Beretta Simone, La Spina Isidoro, Bernasconi Simona, De Santis Tiziana, Cavallini Anna, Ranieri Michela, D'Adda Elisabetta, Fruguglietti Maria Elisa, Peverelli Lorenzo, Agosti Edoardo, Leoni Olivia, Rigamonti Andrea, Salmaggi Andrea
Аннотация
METHODS: Adult patients admitted to 20 Neurological Units between 1/3-30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO).
RESULTS: Thirty-eight COVID19-GBS patients had a mean age of 60.7 years and male frequency of 86.8%. CSF albuminocytological dissociation was detected in 71.4%, and PCR for SARS-CoV-2 was negative in 19 tested patients. Based on neurophysiology, 81.8% of patients had a diagnosis of AIDP, 12.1% of AMSAN, and 6.1% of AMAN. The course was favorable in 76.3% of patients, stable in 10.5%, while 13.2% worsened, of which 3 died. The estimated occurrence rate in Lombardia ranges from 0.5 to 0.05 GBS cases per 1000 COVID-19 infections depending on whether you consider positive cases or estimated seropositive cases. When we compared GBS cases with the pre-pandemic period, we found a reduction of cases from 165 to 135 cases in the 2-month study period in Lombardia.
CONCLUSIONS: We detected an increased incidence of GBS in COVID-19 patients which can reflect a higher risk of GBS in COVID-19 patients and a reduction of GBS events during the pandemic period possibly due to a lower spread of more common respiratory infectious diseases determined by an increased use of preventive measures.