Endocrine · 2019
Sweat and vitamin D status in congenital, lifetime, untreated GH deficiency.
Письмо в редакциюНазвание и аннотация: Перевод пока не подготовлен
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История · было → стало
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Barros-Oliveira Cynthia S, Salvatori Roberto, Dos Santos Jéssica S S, Santos Paula F C, Oliveira-Santos Alécia A, Marinho Cindi G, Santos Elenilde G, Leal Ângela C G B, Campos Viviane C, Damascena Nayra P, Oliveira Carla R P, Aguiar-Oliveira Manuel H
Аннотация
PURPOSE: A reciprocal relationship exists between the skin and the GH/IGF-I axis. Skin produces both IGF- I and vitamin D, and GH and IGF-I exert several actions in the skin. Reduced sweating and altered phosphor-calcium homeostasis are occasionally reported in subjects with GH deficiency (GHD), mostly in the setting of hypopituitarism, therefore associated to other hormonal deficiencies. It is unclear whether these findings are due to GHD. The aim of this study was to assess skin function in subjects with isolated GHD (IGHD) due to a mutation in the GHRH receptor gene.
METHODS: In a cross-sectional study we enrolled 20 IGHD and 20 local controls. Sweating (volume, conductivity and chloride content) was assessed by a 30 min pilocarpine iontophoresis test, using the Macroduct® Sweat Collection System. IGF-I, Insulin, PTH, 25-hydroxyvitamin D, C-reactive protein (CRP), CPK, glucose, calcium, phosphate, alkaline phosphatase, total proteins and fractions, urinary calcium, and insulin were measured. HOMA-IR was calculated.
RESULTS: IGHD presented lower sweating, but normal vitamin D and phosphor-calcium homeostasis. Additionally, IGHD subjects presented lower HOMA-IR, higher CRP and reduced CPK.
CONCLUSION: Untreated IGHD cause reduction in sweating, but does not affect phosphor-calcium homeostasis.
METHODS: In a cross-sectional study we enrolled 20 IGHD and 20 local controls. Sweating (volume, conductivity and chloride content) was assessed by a 30 min pilocarpine iontophoresis test, using the Macroduct® Sweat Collection System. IGF-I, Insulin, PTH, 25-hydroxyvitamin D, C-reactive protein (CRP), CPK, glucose, calcium, phosphate, alkaline phosphatase, total proteins and fractions, urinary calcium, and insulin were measured. HOMA-IR was calculated.
RESULTS: IGHD presented lower sweating, but normal vitamin D and phosphor-calcium homeostasis. Additionally, IGHD subjects presented lower HOMA-IR, higher CRP and reduced CPK.
CONCLUSION: Untreated IGHD cause reduction in sweating, but does not affect phosphor-calcium homeostasis.