Revue des maladies respiratoires · 2026
[A rare cause of mediastino-pulmonary granulomatosis associated with Whipple's disease].
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Pinto M, Nguyen Van R, Marquette D
Аннотация
INTRODUCTION: As a rare bacterial infection caused by Tropheryma whipplei, Whipple's disease often manifests systemically, most commonly with rheumatological and/or digestive symptoms. An unusual pulmonary pathology, it may be considered as non-specific granulomatosis.
CASE REPORT: We report on the case of a 57-year-old man presenting with mediastinal lymphadenopathy, which was discovered incidentally during an episode of pulmonary embolism. Notwithstanding negative bacterial cultures, adenomegaly PCR testing confirmed the hypothesis of T. whipplei infection. Following antibiotic therapy, significant clinical and radiological improvements were observed.
CONCLUSION: Although uncommon, Whipple's disease should be considered as a possibility when unexplained granulomatous pulmonary involvement occurs. An early diagnosis, followed by appropriate antibiotic therapy, generally leads to a favorable outcome.
CASE REPORT: We report on the case of a 57-year-old man presenting with mediastinal lymphadenopathy, which was discovered incidentally during an episode of pulmonary embolism. Notwithstanding negative bacterial cultures, adenomegaly PCR testing confirmed the hypothesis of T. whipplei infection. Following antibiotic therapy, significant clinical and radiological improvements were observed.
CONCLUSION: Although uncommon, Whipple's disease should be considered as a possibility when unexplained granulomatous pulmonary involvement occurs. An early diagnosis, followed by appropriate antibiotic therapy, generally leads to a favorable outcome.