Anticancer research · 2017
Induced Pluripotent-stem-cell Related Genes Contribute to De-differentiation in Oral Squamous Cell Carcinoma.
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Takeda Daisuke, Hasegawa Takumi, Ueha Takeshi, Iwata Eiji, Harada Risa, Sakakibara Akiko, Kawamoto Teruya, Minamikawa Tsutomu, Sakai Yoshitada, Komori Takahide
Аннотация
BACKGROUND/AIM: Cancer stem cells are suspected to contribute to malignancy in tumors. Hypoxia affects cell differentiation and induces stem-cell-like characteristics in malignancies. Induced pluripotency was demonstrated in mouse fibroblasts by reprogramming with four transcriptional factors: Oct3/4, Sox2, c-Myc, and Klf4. Conversely, oncogenic transformations frequently express transcriptional factors and Nanog. Therefore, cancer cells present some similarities with induced pluripotent stem (iPS) cells.
MATERIALS AND METHODS: We investigated the expression of iPS-related genes in vitro and in clinical samples to identify their relationships with hypoxia and tumorigenesis.
RESULTS: Oral squamous cell carcinoma (SCC) cells were used to show that expression levels of Oct3/4, Sox2, and Nanog were significantly increased in hypoxic condition in vitro and in moderately- and poorly-differentiated samples.
CONCLUSION: We propose that Oct3/4, Sox2 and Nanog are associated with tumor hypoxia characterized in oral SCC and that these factors may also contribute to the undifferentiated potency observed in oral SCC clinically.
MATERIALS AND METHODS: We investigated the expression of iPS-related genes in vitro and in clinical samples to identify their relationships with hypoxia and tumorigenesis.
RESULTS: Oral squamous cell carcinoma (SCC) cells were used to show that expression levels of Oct3/4, Sox2, and Nanog were significantly increased in hypoxic condition in vitro and in moderately- and poorly-differentiated samples.
CONCLUSION: We propose that Oct3/4, Sox2 and Nanog are associated with tumor hypoxia characterized in oral SCC and that these factors may also contribute to the undifferentiated potency observed in oral SCC clinically.
Предметные рубрики MeSH
AdultAgedAged, 80 and overCarcinogenesisCarcinoma, Squamous CellCell DifferentiationCell Line, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansHypoxiaInduced Pluripotent Stem CellsKruppel-Like Factor 4MaleMiddle AgedMouth NeoplasmsNanog Homeobox ProteinOctamer Transcription Factor-3PrognosisSOXB1 Transcription Factors