Thorax · 2026
No association between troponin and COPD without cardiovascular influence: findings from a population-based cohort (SCAPIS).
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Eriksson Ström Jonas, Pesonen Ida, Liv Per, Andersson Anders, Bossios Apostolos, Egesten Arne, Ekström Magnus, Engvall Jan, Good Elin, Hammarsten Ola, Holm Jonas, Janson Christer, Johnsson Åse, Lind Lars, Lindberg Eva, Lindén Anders, Malinovschi Andrei, Moberg Anna, Nilsson Ulf, Palmqvist Emma, Skold Magnus, Sundh Josefin, Tanash Hanan A, Zaigham Suneela, Blomberg Anders
Аннотация
Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26; highest category vs below limit of detection) or with forced expiratory volume in 1 s/forced vital capacity (adjusted difference 0.002, 95% CI -0.001 to 0.004). Median TnI was 2.2 ng/L in both obstructive and non-obstructive groups. These findings do not support a pulmonary source of TnI elevation in mild to moderate, stable COPD and suggest that TnI elevations should prompt cardiovascular evaluation rather than being attributed to pulmonary disease alone.