Clinica chimica acta; international journal of clinical chemistry · 2026
Clinical chemistry reference intervals in clinically validated healthy individuals: A large single-center study.
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Elferink Rob F M Oude, Wübbels Shirly A M, Sloots Geert, Koster Anja, Brouwer Jan Leendert P
Аннотация
BACKGROUND: Accurate reference intervals (RIs) for laboratory test results are essential in clinical practice. To enhance clinical decision-making, refined RIs are needed. Therefore a single-center study was performed with extensively evaluated healthy participants, measuring a large set of biochemical markers.
METHODS: In this descriptive, quantitative, a priori direct sampling, single-center study, a total of 18,701 determinations were collected from 8380 healthy adults aged 18 years and older. Age- and sex-specific RIs were established for 36 biochemical assays.
RESULTS: Serum concentrations of several biochemical assays remained relatively constant across the adult age range and were similar between sexes (e.g., total calcium, chloride and sodium). Other biochemical assays (e.g., alanine-amino transferase, triglycerides) showed differences, indicating the influence of factors such as age and sex on the observed results.
CONCLUSIONS: For the first time in Europe, we established age- and sex-specific RIs for 36 biochemical assays using data from extensively clinically validated healthy participants.
METHODS: In this descriptive, quantitative, a priori direct sampling, single-center study, a total of 18,701 determinations were collected from 8380 healthy adults aged 18 years and older. Age- and sex-specific RIs were established for 36 biochemical assays.
RESULTS: Serum concentrations of several biochemical assays remained relatively constant across the adult age range and were similar between sexes (e.g., total calcium, chloride and sodium). Other biochemical assays (e.g., alanine-amino transferase, triglycerides) showed differences, indicating the influence of factors such as age and sex on the observed results.
CONCLUSIONS: For the first time in Europe, we established age- and sex-specific RIs for 36 biochemical assays using data from extensively clinically validated healthy participants.