Emerging infectious diseases · 2012
Intestinal toxemia botulism in 3 adults, Ontario, Canada, 2006-2008.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Sheppard Yolanda D, Middleton Dean, Whitfield Yvonne, Tyndel Felix, Haider Shariq, Spiegelman Jamie, Swartz Richard H, Nelder Mark P, Baker Stacey L, Landry Lisa, Maceachern Ross, Deamond Sherri, Ross Lorrie, Peters Garth, Baird Michelle, Rose David, Sanders Greg, Austin John W
Аннотация
Five cases of intestinal toxemia botulism in adults were identified within an 18-month period in or near Toronto, Ontario, Canada. We describe findings for 3 of the 5 case-patients. Clinical samples contained Clostridium botulinum spores and botulinum neurotoxins (types A and B) for extended periods (range 41-61 days), indicative of intestinal toxemia botulism. Patients' clinical signs improved with supportive care and administration of botulinum antitoxin. Peanut butter from the residence of 1 case-patient yielded C. botulinum type A, which corresponded with type A spores found in the patient's feces. The food and clinical isolates from this case-patient could not be distinguished by pulsed-field gel electrophoresis. Two of the case-patients had Crohn disease and had undergone previous bowel surgery, which may have contributed to infection with C. botulinum. These cases reinforce the view that an underlying gastrointestinal condition is a risk factor for adult intestinal toxemia botulism.