Journal of the American Academy of Dermatology · 1993
Histologic features of foreign body reactions in patients infected with human immunodeficiency virus type 1. The Military Medical Consortium for Applied Retroviral Research.
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Smith K J, Skelton H G, Yeager J, Angritt P, Wagner K F
Аннотация
BACKGROUND: Within a large population of patients seropositive for human immunodeficiency virus type 1 (HIV-1), seven had biopsy specimens that showed foreign body reactions with histologic features different from those seen in non-HIV-1-positive patients.
OBJECTIVE: These cases were reviewed to determine whether there was a specific pattern of response to foreign bodies in HIV-1 infection and whether this pattern was related to the stage of disease.
METHODS: Biopsy specimens were reviewed to identify ruptured epidermal cysts. These were studied in routine hematoxylin-and-eosin-stained sections and with immunohistochemical stains to characterize the inflammatory infiltrate.
RESULTS: The lesions in HIV-1-infected patients contained abundant macrophages with evidence of decreased function and a lack of giant cells.
CONCLUSION: These histologic features suggest an early functional deficit before there is a significant decrease in the number of T4 lymphocytes.
OBJECTIVE: These cases were reviewed to determine whether there was a specific pattern of response to foreign bodies in HIV-1 infection and whether this pattern was related to the stage of disease.
METHODS: Biopsy specimens were reviewed to identify ruptured epidermal cysts. These were studied in routine hematoxylin-and-eosin-stained sections and with immunohistochemical stains to characterize the inflammatory infiltrate.
RESULTS: The lesions in HIV-1-infected patients contained abundant macrophages with evidence of decreased function and a lack of giant cells.
CONCLUSION: These histologic features suggest an early functional deficit before there is a significant decrease in the number of T4 lymphocytes.