Academic radiology · 2026
In Vivo Quantification of Relaxation Times of Abdominal Tissues at 5.0 T MRI: A Preliminary Study in Healthy Volunteers.
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Dong Xue, Yang Huai, Xu Hui, Yu Dan, Wang Kewei, Yang Zhenghan, Yang Dawei
Аннотация
OBJECTIVES: To establish normative T1 and T2 relaxation times for the liver, pancreas, and kidneys at 5.0 T MRI, providing reference data for imaging parameter optimization and quantitative diagnosis.
MATERIALS AND METHODS: Standardized T1/T2 phantoms were used for in vitro validation. From January to March 2025, healthy adults underwent 5.0 T abdominal MRI. T1/T2 maps were obtained using Modified Look-Locker Inversion Recovery (MOLLI) and T2-prepared gradient echo (T2 prep) sequences. Values, reproducibility, and correlations with age, sex, and other factors were evaluated.
RESULTS: Results from the 10 tubes showed excellent agreement with MOLLI-based T1 and T2-prep-based T2 values and reference standards. The final cohort consisted of 41 participants. In healthy volunteers at 5.0 T MRI, mean T1 values were 1131.68±123.03ms(liver), 1164.63±57.81ms(pancreas), 1753.62±80.44ms (kidney cortex), and 2175.06±100.80ms (kidney medulla); mean T2 values were 31.16±3.37ms, 47.48±4.55ms, 59.36±6.35ms, and 41±4.07ms, respectively. T1 and T2 showed excellent reproducibility. Correlation analysis demonstrated a significant linear negative correlation between R2* and liver T1, and the R2* corrected liver T1 was 1156.57±69.25ms. Liver T2 decreased with age, and both measured and corrected liver T1 decreased with waist-to-hip ratio. Measured T1 and T2 of liver and kidney (cortex and medulla) were all lower in males than females, but liver corrected T1 showed no sex difference.
CONCLUSION: This study reports normative T1 and T2 relaxation times of the liver, pancreas, renal cortex, and medulla at 5.0 T MRI, confirming the method's feasibility and reproducibility, thus providing reference values for parameter optimization and future disease-related research.
KEY POINTS: Question Quantitative 5.0 T MRI is diagnostically significant, but normative reference values for abdominal T1/T2 relaxation times are currently lacking. Findings We established normative T1/T2 values for abdominal organs at 5.0 T MRI, providing a reference for protocol optimization and diagnosis. Clinical relevance This study establishes normative T1 and T2 relaxation times for abdominal organs at 5.0 T MRI. These reproducible, quantitative reference values are essential for optimizing imaging protocols and provide a robust baseline for diagnosing abdominal diseases.
MATERIALS AND METHODS: Standardized T1/T2 phantoms were used for in vitro validation. From January to March 2025, healthy adults underwent 5.0 T abdominal MRI. T1/T2 maps were obtained using Modified Look-Locker Inversion Recovery (MOLLI) and T2-prepared gradient echo (T2 prep) sequences. Values, reproducibility, and correlations with age, sex, and other factors were evaluated.
RESULTS: Results from the 10 tubes showed excellent agreement with MOLLI-based T1 and T2-prep-based T2 values and reference standards. The final cohort consisted of 41 participants. In healthy volunteers at 5.0 T MRI, mean T1 values were 1131.68±123.03ms(liver), 1164.63±57.81ms(pancreas), 1753.62±80.44ms (kidney cortex), and 2175.06±100.80ms (kidney medulla); mean T2 values were 31.16±3.37ms, 47.48±4.55ms, 59.36±6.35ms, and 41±4.07ms, respectively. T1 and T2 showed excellent reproducibility. Correlation analysis demonstrated a significant linear negative correlation between R2* and liver T1, and the R2* corrected liver T1 was 1156.57±69.25ms. Liver T2 decreased with age, and both measured and corrected liver T1 decreased with waist-to-hip ratio. Measured T1 and T2 of liver and kidney (cortex and medulla) were all lower in males than females, but liver corrected T1 showed no sex difference.
CONCLUSION: This study reports normative T1 and T2 relaxation times of the liver, pancreas, renal cortex, and medulla at 5.0 T MRI, confirming the method's feasibility and reproducibility, thus providing reference values for parameter optimization and future disease-related research.
KEY POINTS: Question Quantitative 5.0 T MRI is diagnostically significant, but normative reference values for abdominal T1/T2 relaxation times are currently lacking. Findings We established normative T1/T2 values for abdominal organs at 5.0 T MRI, providing a reference for protocol optimization and diagnosis. Clinical relevance This study establishes normative T1 and T2 relaxation times for abdominal organs at 5.0 T MRI. These reproducible, quantitative reference values are essential for optimizing imaging protocols and provide a robust baseline for diagnosing abdominal diseases.