Oral surgery, oral medicine, oral pathology and oral radiology · 2013
Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters.
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Horii Koichiro, Kanayama Takeo, Miyamoto Hironori, Kohgo Tomoyuki, Tsuchimochi Tsukasa, Shigetomi Toshio, Yokoi Motoo
Аннотация
OBJECTIVE: The aim of this study was to evaluate the healing effect of topically applied platelet-rich fibrin (PRF) on experimental oral mucositis induced by chemotherapy in hamsters.
STUDY DESIGN: Oral mucositis was induced in 93 Syrian golden hamsters by an intraperitoneal injection of 5-fluorouracil, which was followed by light scratching of the cheek pouch. The hamsters were randomly divided into a PRF group, a fibrin group, and an untreated control group. The recovery stage of oral mucositis was evaluated through daily weighing, measurements of the ulcer area, histopathologic analysis, and a myeloperoxidase activity assay.
RESULTS: The PRF group exhibited significant improvements in the size and histologic features of the ulcer and in the myeloperoxidase activity compared with the control group (P < .05).
CONCLUSIONS: The current findings suggest the consideration for future clinical trials in humans.
STUDY DESIGN: Oral mucositis was induced in 93 Syrian golden hamsters by an intraperitoneal injection of 5-fluorouracil, which was followed by light scratching of the cheek pouch. The hamsters were randomly divided into a PRF group, a fibrin group, and an untreated control group. The recovery stage of oral mucositis was evaluated through daily weighing, measurements of the ulcer area, histopathologic analysis, and a myeloperoxidase activity assay.
RESULTS: The PRF group exhibited significant improvements in the size and histologic features of the ulcer and in the myeloperoxidase activity compared with the control group (P < .05).
CONCLUSIONS: The current findings suggest the consideration for future clinical trials in humans.