Медицинская библиотека · Oral surgery, oral medicine, oral pathology and oral radiology · 2013

Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters.

Horii Koichiro, Kanayama Takeo, Miyamoto Hironori, Kohgo Tomoyuki, Tsuchimochi Tsukasa, Shigetomi Toshio, Yokoi Motoo

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

The aim of this study was to evaluate the healing effect of topically applied platelet-rich fibrin (PRF) on experimental oral mucositis induced by chemotherapy in hamsters.

STUDY

DESIGN

Oral mucositis was induced in 93 Syrian golden hamsters by an intraperitoneal injection of 5-fluorouracil, which was followed by light scratching of the cheek pouch. The hamsters were randomly divided into a PRF group, a fibrin group, and an untreated control group. The recovery stage of oral mucositis was evaluated through daily weighing, measurements of the ulcer area, histopathologic analysis, and a myeloperoxidase activity assay.

RESULTS

The PRF group exhibited significant improvements in the size and histologic features of the ulcer and in the myeloperoxidase activity compared with the control group (P < .05).

CONCLUSIONS

The current findings suggest the consideration for future clinical trials in humans.

Для цитирования: Horii Koichiro, Kanayama Takeo, Miyamoto Hironori, Kohgo Tomoyuki, Tsuchimochi Tsukasa, Shigetomi Toshio, Yokoi Motoo. Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters.. Oral surgery, oral medicine, oral pathology and oral radiology. 2013. DOI: 10.1016/j.oooo.2013.12.004.

Предметные рубрики MeSH

Administration, Topical Animals Blood Platelets Cricetinae Disease Models, Animal Fibrin Fluorouracil Male Mesocricetus Peroxidase Random Allocation Stomatitis Wound Healing

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