Incidence and prevalence of primary biliary cholangitis in the Netherlands - A nationwide cohort study.
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de Veer Rozanne C, van Hooff Maria C B, Werner Ellen, Beuers Ulrich, Drenth Joost P H, Cuperus Frans J C, van Hoek Bart, Veldt Bart J, Klemt-Kropp Michael, van Meer Suzanne, Verdonk Robert C, Flink Hajo J, Vrolijk Jan Maarten, Gevers Tom J G, Ponsioen Cyriel Y, Ter Borg Martijn J, Soufidi Khalida, Boersma Femke, de Jonge Hendrik J M, Wolfhagen Frank H J, Baak L C, Onderwater Susanne L, van Bergeijk Jeroen D, van Putten Paul G, de Bruin Gijs J, Adang Rob P R, Aparicio-Pages Maria N, de Boer Wink, Borg Frank Ter, van Soest Hanneke, Janssen Harry L A, Hansen Bettina E, Erler Nicole S, van der Meer Adriaan J, Dutch PBC Study Group
Аннотация
METHODS: DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and age groups over time.
RESULTS: On the 1st of January 2008, there were 1,458 patients with PBC in the Netherlands. Between 2008-2018, 2,187 individuals were newly diagnosed, 46 were transplanted and 468 died. The yearly incidence of PBC in 2008 was 1.38, increasing to 1.74 per 100,000 persons in 2018. When compared to those aged <45 years, females aged 45-64 years (adjusted incidence rate ratio 4.21, 95% CI 3.76-4.71, p <0.001) and males ≥65 years (adjusted incidence rate ratio 14.41, 95% CI 9.62-21.60, p <0.001) were at the highest risk of being diagnosed with PBC. The male-to-female ratio of patients newly diagnosed with PBC during the study period was 1:14 in those <45 years, 1:10 in patients aged 45-64 years, and 1:4 in those ≥65 years. Point prevalence increased from 11.9 in 2008 to 21.5 per 100,000 persons in 2018. Average annual percent change in this time period was 5.94% (95% CI 5.77-6.15, p <0.05), and was the highest among the population aged ≥65 years (5.69%, 95% CI 5.32-6.36, p <0.001).
CONCLUSIONS: In this nationwide cohort study, we observed an increase in both the incidence and prevalence of PBC in the Netherlands over the past decade, with marked age and sex differences.
IMPACT AND IMPLICATIONS: This nationwide Dutch primary biliary cholangitis (PBC) Cohort Study, including all hospitals in the Netherlands, showed that the incidence and prevalence of PBC have increased over the last decade. The age-dependent PBC incidence rate differed for males (highest risk ≥65 years) and females (highest risk between 45 and 65 years), which may be related to a difference in the timing of exposure to environmental triggers of PBC. The largest increase in PBC prevalence over time was observed in the population aged ≥65 years, which may have implications for the use of second-line therapies. These results therefore indicate that further studies are needed to elaborate on the advantages and disadvantages of add-on therapies in the elderly population.