The evolution of geriatric neurology.

The founders of neurology in the late 19th century and early 20th century laid the foundation for modern geriatric neurology by detailed observations, in their patients, of the clinical expressions of aging of the nervous system. Further advances in clinical manifestations of aging and more detailed examination of disease states in the elderly accelerated in the last quarter of the 20th century. Basic, translational, and clinical research support of geriatric neurology studies expanded and advanced during this period and into the 21st century. The size and sophistication of this movement was stimulated by a number of factors: the successful development of geriatrics as a specialty in primary care, internal medicine, and psychiatry; the projected growth of the geriatric population; and the projections of the number of people with Alzheimer's disease. However, there were and continue to be inadequate numbers of trained geriatric neurologists available to care for the "silver tsunami" of elderly patients with age-related diseases that will present in the next 3 decades. The combination of massive investment in dementia/Alzheimer's research in the past decade, widespread awareness among researchers and trainees of the opportunities to do research in age-related diseases, and the need for further knowledge of neurodegenerative diseases led to a broad expansion of research efforts. Longitudinal clinical studies of the elderly and the advent of sophisticated neuroimaging, genetics, and laboratory techniques are advancing the field. The initiation of therapeutic interventions has led to cautious optimism about the ability to ameliorate suffering in these patients and diminish the burdens of central nervous system aging.