Alzheimer's & dementia (Amsterdam, Netherlands) · 2019
Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk.
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Gagliano Taliun Sarah A
Аннотация
INTRODUCTION: There is observational evidence that low circulating levels of vitamin B12 are associated with an increased risk of Alzheimer's disease.
METHODS: We used a two-sample summary-statistics-based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late-onset Alzheimer's disease risk.
RESULTS: Our results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk.
DISCUSSION: This work encourages research on other modifiable biomarkers for Alzheimer's disease risk.
METHODS: We used a two-sample summary-statistics-based Mendelian randomization design to assess the relationship of genetic factors contributing to vitamin B12 with late-onset Alzheimer's disease risk.
RESULTS: Our results do not support a causal role of decreased vitamin B12 levels on Alzheimer's disease risk.
DISCUSSION: This work encourages research on other modifiable biomarkers for Alzheimer's disease risk.