APOE ɛ4 and REM Sleep Behavior Disorder as Risk Factors for Sundown Syndrome in Alzheimer's Disease.

BACKGROUND

Sundown syndrome (SS) in patients with Alzheimer's disease (AD) is characterized by aggravation of behavioral problems at sunset. Disturbance of the circadian rhythm, a possible cause of SS, also facilitates amyloidopathy and reduces sleep quality. However, the associations of SS with amyloidopathy and sleep quality remain unclear.

OBJECTIVE

To investigate the prevalence of SS in patients with AD, the association between SS and APOEɛ4 carrier, representing an enhanced amyloid pathology, and the relationship between SS and sleep quality in AD.

METHODS

We included 104 patients with late-onset AD and known APOE genotype. All participants underwent a structured interview via informant-based questionnaires to assess sleep quality and the presence of SS. Binary logistic regression analysis was performed to determine odds ratios (ORs) of APOEɛ4 carrier and parameters of sleep quality for SS.

RESULTS

The prevalence of SS in AD was 27.8% (n = 29). Patients with SS were significantly more likely to be APOEɛ4 carriers and to have rapid eye movement sleep behavior disorder (RBD) and a higher Clinical Dementia Rating (CDR) score compared to those without SS. In the multivariate regression analysis, APOEɛ4 carrier (OR 3.158, CI 1.022-9.758), RBD (OR 2.166, CI 1.073-4.371), and higher CDR score (OR 2.453, CI 1.084-5.550) were associated with an increased risk of SS.

CONCLUSION

The prevalence of SS in patients with AD was 27.8%. The presence of the APOEɛ4 allele, RBD, and more severe dementia are associated with an increased risk of SS in AD.