Cornea · 2025
Exploring the Gut-Eye Axis: Microbial Dysbiosis in Vernal Keratoconjunctivitis.
СтатьяНазвание и аннотация: Перевод в очереди
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Peyman Alireza, Pourazizi Mohsen, Kazemi Mohammad, Ghorbani Fatemeh, Chitsaz Esfahani Zahra, Ahmadi Beni Faeze, Noorshargh Pegah, Ghorbani Sarah
Аннотация
PURPOSE: To investigates the gut microbiota in patients with vernal keratoconjunctivitis (VKC) compared with normal subjects.
METHOD: A case-control study was conducted involving 32 patients with VKC and 16 age- and sex-matched healthy controls. Fecal samples were collected and analyzed using quantitative PCR to measure the abundance of 5 bacterial groups: Prevotella, Firmicutes, Faecalibacterium, Bifidobacterium, and Bacteroides. In addition, clinical severity scores for VKC symptoms and signs were recorded and analyzed.
RESULTS: Patients with VKC exhibited significant microbial dysbiosis compared with controls, including an upregulation of Prevotella (mean fold change 21.579; P <0.001) and downregulation of Firmicutes, Faecalibacterium, and Bifidobacterium (P < 0.01 for all). No significant correlations were observed between microbial levels and clinical severity scores.
CONCLUSIONS: The study identifies significant gut microbial imbalances in patients with VKC, suggesting that dysbiosis may play a role in the disease. Microbiota-targeted interventions, such as probiotics and dietary modifications, may offer novel strategies for managing VKC.
METHOD: A case-control study was conducted involving 32 patients with VKC and 16 age- and sex-matched healthy controls. Fecal samples were collected and analyzed using quantitative PCR to measure the abundance of 5 bacterial groups: Prevotella, Firmicutes, Faecalibacterium, Bifidobacterium, and Bacteroides. In addition, clinical severity scores for VKC symptoms and signs were recorded and analyzed.
RESULTS: Patients with VKC exhibited significant microbial dysbiosis compared with controls, including an upregulation of Prevotella (mean fold change 21.579; P <0.001) and downregulation of Firmicutes, Faecalibacterium, and Bifidobacterium (P < 0.01 for all). No significant correlations were observed between microbial levels and clinical severity scores.
CONCLUSIONS: The study identifies significant gut microbial imbalances in patients with VKC, suggesting that dysbiosis may play a role in the disease. Microbiota-targeted interventions, such as probiotics and dietary modifications, may offer novel strategies for managing VKC.