Cytokine · 2025
Elevated cytokine levels in patients with High-altitude pulmonary edema.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Binyun, Zhaxi Quzong, Danzeng Zhuoga, Ci Bai, Dingzeng Qiangba, Baima Zhuoga, Gesang Luobu
Аннотация
BACKGROUND: Immunomodulation is integral to the body's adaptation to varying altitudes. Nevertheless, the effects of immune regulation on the onset of high-altitude pulmonary edema (HAPE) are not well understood. This research aimed to explore the influence of immune regulation on HAPE pathogenesis through the assessment of cytokine levels.
METHODS: We analyzed the cytokine profiles of 28 HAPE patients at high altitudes and compared them to 25 healthy individuals who had successfully acclimatized. The levels of seven cytokines released by T helper cells (Th)1/2/17, alongside monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-8, and IL-1β in serum, were quantified using cytometric bead array (CBA) technology.
RESULTS: Our findings revealed significantly higher concentrations of IL-2, IL-10, and tumor necrosis factor (TNF) in the peripheral blood of HAPE patients when contrasted with those of healthy individuals (P < 0.001). A comprehensive analysis of these cytokines indicated a robust diagnostic capability for predicting HAPE, achieving an area under the curve (AUC) of 0.98. Conversely, no significant differences were observed in the levels of IL-6, IL-8, interferon-γ (IFN-γ), IL-4, IL-17 A, MCP-1, and IL-1β between the two cohorts.
CONCLUSIONS: Elevated IL-2, IL-10, and TNF in HAPE patients underscore immune dysregulation as a disease driver. Clinically, these cytokines may guide risk prediction (IL-2-hypoxemia link) and targeted therapies (anti-TNF for vascular leakage). Future work should define hypoxia-specific cytokine networks, validate interventions in altitude cohorts, and integrate multi-omics to map immune-vascular crosstalk.
METHODS: We analyzed the cytokine profiles of 28 HAPE patients at high altitudes and compared them to 25 healthy individuals who had successfully acclimatized. The levels of seven cytokines released by T helper cells (Th)1/2/17, alongside monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-8, and IL-1β in serum, were quantified using cytometric bead array (CBA) technology.
RESULTS: Our findings revealed significantly higher concentrations of IL-2, IL-10, and tumor necrosis factor (TNF) in the peripheral blood of HAPE patients when contrasted with those of healthy individuals (P < 0.001). A comprehensive analysis of these cytokines indicated a robust diagnostic capability for predicting HAPE, achieving an area under the curve (AUC) of 0.98. Conversely, no significant differences were observed in the levels of IL-6, IL-8, interferon-γ (IFN-γ), IL-4, IL-17 A, MCP-1, and IL-1β between the two cohorts.
CONCLUSIONS: Elevated IL-2, IL-10, and TNF in HAPE patients underscore immune dysregulation as a disease driver. Clinically, these cytokines may guide risk prediction (IL-2-hypoxemia link) and targeted therapies (anti-TNF for vascular leakage). Future work should define hypoxia-specific cytokine networks, validate interventions in altitude cohorts, and integrate multi-omics to map immune-vascular crosstalk.