Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2025
Evaluation of the role of human neutrophil elastase, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio as predictive markers for severity of acute respiratory toxicity among patients admitted to Poison Control Center of Ain Shams University Hospitals.
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Mohammed Alaa, Elkotb Mona, Elawady Eglal, Eweda Sarah
Аннотация
BACKGROUND: There are hundreds of xenobiotics that can damage the respiratory system, necessitating mechanical ventilation. Therefore, acute respiratory toxicity may represent a serious condition that can be complicated by acute respiratory distress syndrome (ARDS). This study aimed to evaluate the role of Human Neutrophil Elastase (HNE) as a predictor of acute respiratory toxicity outcome and to compare it with the neutrophil lymphocyte ratio (N/L ratio) and platelet lymphocyte ratio (P/L ratio).
METHODS: This prospective study was conducted on adult patients with acute respiratory toxicity admitted to Poison Control Center; Ain Shams University Hospitals from January 2022 to December 2022. Their HNE, N/L ratio, and P/L ratio levels were assessed twice: First upon admission and again 24 h later.
RESULTS: Fifty-five patients were enrolled in the study and were classified into ARDS group and non-ARDS group. HNE levels were significantly higher in ARDS patients at both time points with excellent predictive performance. Although the N/L and P/L ratios were significantly elevated in ARDS patients at 30 h, their diagnostic performance was inferior to HNE. Combining HNE with the N/L ratio offered minimal additional benefit over HNE alone.
CONCLUSION: HNE Level can serve as predictor of ARDS in acutely intoxicated patients.
METHODS: This prospective study was conducted on adult patients with acute respiratory toxicity admitted to Poison Control Center; Ain Shams University Hospitals from January 2022 to December 2022. Their HNE, N/L ratio, and P/L ratio levels were assessed twice: First upon admission and again 24 h later.
RESULTS: Fifty-five patients were enrolled in the study and were classified into ARDS group and non-ARDS group. HNE levels were significantly higher in ARDS patients at both time points with excellent predictive performance. Although the N/L and P/L ratios were significantly elevated in ARDS patients at 30 h, their diagnostic performance was inferior to HNE. Combining HNE with the N/L ratio offered minimal additional benefit over HNE alone.
CONCLUSION: HNE Level can serve as predictor of ARDS in acutely intoxicated patients.