Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.
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Bailey Jessica N Cooke, Gharahkhani Puya, Kang Jae H, Butkiewicz Mariusz, Sullivan David A, Weinreb Robert N, Aschard Hugues, Allingham R Rand, Ashley-Koch Allison, Lee Richard K, Moroi Sayoko E, Brilliant Murray H, Wollstein Gadi, Schuman Joel S, Fingert John H, Budenz Donald L, Realini Tony, Gaasterland Terry, Scott William K, Singh Kuldev, Sit Arthur J, Igo Robert P, Song Yeunjoo E, Hark Lisa, Ritch Robert, Rhee Douglas J, Vollrath Douglas, Zack Donald J, Medeiros Felipe, Vajaranant Thasarat S, Chasman Daniel I, Christen William G, Pericak-Vance Margaret A, Liu Yutao, Kraft Peter, Richards Julia E, Rosner Bernard A, Hauser Michael A, Craig Jamie E, Burdon Kathryn P, Hewitt Alex W, Mackey David A, Haines Jonathan L, MacGregor Stuart, Wiggs Janey L, Pasquale Louis R, Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium
Аннотация
METHODS: We used two datasets: one from the United States (3853 cases and 33,480 controls) and another from Australia (1155 cases and 1992 controls). Both datasets contained densely called genotypes imputed to the 1000 Genomes reference panel. We used pathway- and gene-based approaches with Pathway Analysis by Randomization Incorporating Structure (PARIS) software to assess the overall association between a panel of single nucleotide polymorphisms (SNPs) in testosterone metabolism genes and POAG. In sex-stratified analyses, we evaluated POAG overall and POAG subtypes defined by maximum IOP (high-tension [HTG] or normal tension glaucoma [NTG]).
RESULTS: In the US dataset, the SNP panel was not associated with POAG (permuted P = 0.77), although there was an association in the Australian sample (permuted P = 0.018). In both datasets, the SNP panel was associated with POAG in men (permuted P ≤ 0.033) and not women (permuted P ≥ 0.42), but in gene-based analyses, there was no consistency on the main genes responsible for these findings. In both datasets, the testosterone pathway association with HTG was significant (permuted P ≤ 0.011), but again, gene-based analyses showed no consistent driver gene associations.
CONCLUSIONS: Collectively, testosterone metabolism pathway SNPs were consistently associated with the high-tension subtype of POAG in two datasets.