Frontiers in neurology · 2026
Electroacupuncture improves upper-limb motor function and modulates sensorimotor network connectivity in subacute stroke: a randomized controlled trial.
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Li Mingfen, Zou Weigeng, Xie Genggeng, Li Man, Zheng Su, Li Haifeng
Аннотация
OBJECTIVE: Electroacupuncture (EA) has been shown to facilitate post-stroke motor recovery; however, the underlying neurophysiological mechanisms remain insufficiently understood. This study aimed to investigate how EA modulates sensorimotor network (SMN) connectivity and to explore its relationship with upper-limb motor recovery in patients with subacute stroke.
METHODS: Fifty patients with subacute stroke were randomly assigned to the EA group or sham EA (SEA) group. All participants received 18 treatment sessions over 3 weeks in addition to standard rehabilitation. Upper-limb motor function and daily living ability were assessed before and after treatment. Resting-state electroencephalography (EEG) was recorded before and after the intervention. Functional connectivity (FC) within the SMN was calculated using phase-locking value (PLV) in the alpha (8-13 Hz) and beta (13-30 Hz) bands. Graph-theoretical metrics were analyzed, and partial least squares regression (PLSR) was used to evaluate associations between FC alterations and motor improvement.
RESULTS: After treatment, the EA group showed significantly greater improvement in upper-limb motor function than the SEA group, as indicated by a significant group × time interaction for the Fugl-Meyer Assessment for Upper Extremity (FMA-UE) and greater between-group gains in change scores (p < 0.05). For the Modified Barthel Index (MBI), significant main effects of time and group were observed, but the group × time interaction was not significant, although Week 3 scores were higher in the EA group (p < 0.05). EEG analysis showed that alpha-band SMN FC significantly increased after EA, whereas no significant changes were observed in the SEA group (p < 0.05). Between-group comparisons revealed higher post-treatment alpha-band FC in the EA group, predominantly involving interhemispheric connections (p < 0.05). In the EA group, PLSR explained 68.7% of the variance in motor improvement (R2 = 0.687; RMSE = 7.68), whereas no valid predictors were identified in the SEA group. No significant differences were found in global network topology metrics (p > 0.05).
CONCLUSION: EA improved upper-limb motor recovery in patients with subacute stroke and was accompanied by selective enhancement of alpha-band functional connectivity within the sensorimotor network. These findings suggest that EA may promote post-stroke motor recovery through frequency-specific reorganization of recovery-relevant sensorimotor circuits.
CLINICAL TRIAL REGISTRATION: https://www.chictr.org.cn/bin/project/edit?pid=199590, Chinese Clinical Trial Registry (Registration number: ChiCTR2300077420).
METHODS: Fifty patients with subacute stroke were randomly assigned to the EA group or sham EA (SEA) group. All participants received 18 treatment sessions over 3 weeks in addition to standard rehabilitation. Upper-limb motor function and daily living ability were assessed before and after treatment. Resting-state electroencephalography (EEG) was recorded before and after the intervention. Functional connectivity (FC) within the SMN was calculated using phase-locking value (PLV) in the alpha (8-13 Hz) and beta (13-30 Hz) bands. Graph-theoretical metrics were analyzed, and partial least squares regression (PLSR) was used to evaluate associations between FC alterations and motor improvement.
RESULTS: After treatment, the EA group showed significantly greater improvement in upper-limb motor function than the SEA group, as indicated by a significant group × time interaction for the Fugl-Meyer Assessment for Upper Extremity (FMA-UE) and greater between-group gains in change scores (p < 0.05). For the Modified Barthel Index (MBI), significant main effects of time and group were observed, but the group × time interaction was not significant, although Week 3 scores were higher in the EA group (p < 0.05). EEG analysis showed that alpha-band SMN FC significantly increased after EA, whereas no significant changes were observed in the SEA group (p < 0.05). Between-group comparisons revealed higher post-treatment alpha-band FC in the EA group, predominantly involving interhemispheric connections (p < 0.05). In the EA group, PLSR explained 68.7% of the variance in motor improvement (R2 = 0.687; RMSE = 7.68), whereas no valid predictors were identified in the SEA group. No significant differences were found in global network topology metrics (p > 0.05).
CONCLUSION: EA improved upper-limb motor recovery in patients with subacute stroke and was accompanied by selective enhancement of alpha-band functional connectivity within the sensorimotor network. These findings suggest that EA may promote post-stroke motor recovery through frequency-specific reorganization of recovery-relevant sensorimotor circuits.
CLINICAL TRIAL REGISTRATION: https://www.chictr.org.cn/bin/project/edit?pid=199590, Chinese Clinical Trial Registry (Registration number: ChiCTR2300077420).